The product types manufactured with microbial expression systems at Richter-Helm BioLogics include recombinant proteins and peptides, antibody-like scaffolds (VHH/Nanobodies, Fab-fragments), plasmid DNA, and bacterial vaccines.

Recombinant proteins account for the largest share. But Richter-Helm BioLogics has also accumulated extensive experience with many other proteins such as antibody-like scaffolds (e.g. VHH/Nanobodies, Fab-fragments), cytokines, and hormones.

Encouraging therapeutic successes have recently been reported for various gene therapies. Plasmid DNA (pDNA) is an important molecule not only in this field. Plasmids are produced as critical raw materials and serve as starting material for e.g. mRNA and RNAi and provide the DNA template  for virus production (e.g. AAV and Lentivirus) and cell-free expression systems. Our scalable, high-performance, proprietary pDNA process RHB-pART offers high purification success with high ratio of supercoiled pDNA (≥95 %).

Richter-Helm BioLogics has been producing and analytically testing plasmid DNA for nearly 25 years.


The bacterial vaccines produced at Richter-Helm BioLogics include living, attenuated, and inactivated whole-cell vaccines, cell fragments, and surface polymers.

Richter-Helm BioLogics also leverages considerable experience with and flexibility for complex biopharmaceuticals.

All kinds of microbial-derived biopharmaceuticals can be produced at Richter-Helm BioLogics. Recombinant protein projects account for the bulk of the manufacturing services we provide.

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Close-up of a DNA double helix
25 years of experience with pDNA projects. Audited by major authorities including but not limited to FDA, EMA, PMDA.

More than 30-years track record in gmp production of proteins. From gene of interest to product, we flexibly manufacture your target molecule.

If you have any questions or suggestions, we will be happy to advise you